**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: Propylene glycol
Catalog Numbers:
BW11925200, P355 1, P355 20, P355 200, P355 4, P355-1, P355-20, P355-200,
P355-4, P3551, P35520, P355200, P3554, S80150, S80150-1
Synonyms:
1,2-Dihydroxypropane; Methylethylene glycol; Monopropylene glycol;
Propane-1,2-diol; alpha-Propyleneglycol; 1,2-Propylene glycol;
1,2-Propanediol
Company Identification: Fisher Scientific
1 Reagent Lane
Fairlawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 57-55-6 |Propylene glycol | ca. 100 | 200-338-0 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: None Listed.
Risk Phrases: None Listed.
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Hygroscopic.
Potential Health Effects
Eye:
Causes mild eye irritation. Contact may cause irritation, tearing,
and burning pain.
Skin:
Causes moderate skin irritation. Contact with the skin may cause
erythema, dryness, and defatting.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. Low hazard for usual industrial handling. May cause
hemoglobinuric nephrosis. May cause changes in surface EEG.
Inhalation:
Low hazard for usual industrial handling. May cause respiratory
tract irritation.
Chronic:
May cause reproductive and fetal effects. Laboratory experiments
have resulted in mutagenic effects. Exposure to large doses may cause
central nervous system depression. Chronic ingestion may cause lactic
acidosis and possible seizures.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of soap and
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid if cough or other symptoms appear.
Notes to Physician:
Persons with impaired kidney function may be more susceptible to the
effects of this substance. Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Vapors may
be heavier than air. They can spread along the ground and collect
in low or confined areas.
Extinguishing Media:
Use alcohol foam. Cool containers with flooding quantities of water
until well after fire is out.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Avoid contact with
eyes, skin, and c 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR :1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Appearance: colorless viscous liquid
Odor: Odorless
pH: Not available.
Vapor Pressure: 0.08 mm Hg @ 20C
Vapor Density: 2.62
Evaporation Rate: Not available.
Viscosity: 0.581 P@25C
Boiling Point: 188.2 deg C
Freezing/Melting Point: -59 deg C
Autoignition Temperature: 414 deg C ( 777.20 deg F)
Flash Point: 107 deg C ( 224.60 deg F)
Explosion Limits, lower: 2.6 vol %
Explosion Limits, upper: 12.6 vol %
Decomposition Temperature:
Solubility: Miscible.
Specific Gravity/Density: 1.0360g/cm3
Molecular Formula: C3H8O2
Molecular Weight: 76.09
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acid chlorides, nitric acid, acid
anhydrides, silver nitrate, hydrofluoric acid, chloroformates,
moisture.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide, acetic acid, propionaldehyde, lactic acid, pyruvic acid.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 57-55-6: TY2000000
LD50/LC50:
CAS# 57-55-6: Draize test, rabbit, eye: 100 mg Mild; Draize test,
rabbit, eye: 500 mg/24H Mild; Oral, mouse: LD50 = 22 gm/kg; Oral,
rabbit: LD50 = 18500 mg/kg; Oral, rat: LD50 = 20 gm/kg; Skin,
rabbit: LD50 = 20800 mg/kg.
Carcinogenicity:
Propylene glycol -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
No information available.
Teratogenicity:
Intraperitoneal, mouse: TDLo = 100 mg/kg (female 15 day(s) after
conception) Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus).
Reproductive Effects:
Intraperitoneal, mouse: TDLo = 100 mg/kg (female 11 day(s) after
conception) Fertility - post-implantation mortality (e.g. dead
and/or resorbed implants per total number of implants).
Neurotoxicity:
No information available.
Mutagenicity:
DNA Inhibition: Subcutaneous, mouse = 8000 mg/kg.; Cytogenetic
Analysis: Subcutaneous, mouse = 8000 mg/kg.; Cytogenetic Analysis:
Hamster, Fibroblast = 32 gm/L.
Other Studies:
Standard Draize Test: Administration into the eye (rabbit) = 100 mg
(Mild). Standard Draize Test: Administration into the eye (rabbit) =
500 mg/24H (Mild). Standard Draize Test: Administration onto the skin
(human) = 500 mg/7days (Mild). Standard Draize Test: Administration
onto the skin (human) = 104 mg/3 days-Intermittent (Moderate).
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Water f/TT>
biodegradation. If released to soil, relatively rapid biodegradation
should also occur. Significant leaching in soil can be predicted.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
US DOT
No information available
Canadian TDG
No information available.
**** SECTION 15 - REGULATORY INFORMATION ****
US FEDERAL
TSCA
CAS# 57-55-6 is listed on the TSCA inventory.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
Propylene glycol can be found on the following state right to know
lists: Pennsylvania, Minnesota.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 57-55-6: 0
United Kingdom Occupational Exposure Limits
CAS# 57-55-6: OES-United Kingdom, TWA total (vapour and
particulates): 150 ppm TWA; 474 mg/m3 TWA
CAS# 57-55-6: OES-United Kingdom, STEL particulates: 10 ppm STEL
Canada
CAS# 57-55-6 is listed on Canada's DSL List.
CAS# 57-55-6 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 5/27/1999 Revision #2 Date: 8/02/2000
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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