MSDS Name: Formamide
Catalog Numbers: BP227-100, BP227-500, BP228-100, F84-1
Synonyms: Carbamaldehyde; Methanamide.
Company Identification:
              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887

Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
75-12-7	Formamide	>99.5	200-842-0

Hazard Symbols: T
Risk Phrases: 61

Section 3 - Hazards Identification

Appearance: clear, colorless liquid. Warning! Causes eye and skin irritation. May cause reproductive and fetal effects. Hygroscopic (absorbs moisture from the air). Harmful if swallowed, inhaled, or absorbed through the skin. Causes respiratory tract irritation. May cause central nervous system effects.
Target Organs: Central nervous system, liver, eyes, reproductive system, skin, mucous membranes.
Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. Harmful if absorbed through the skin. Not expected to cause an allergic skin reaction. Studies have shown that formamide can be absorbed through the skin in quantities sufficient to produce systemic toxicity even though it is n ot very acutely toxic via this route and effective doses were relative ly high.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. May cause central nervous system effects.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation.
Chronic: Prolonged or repeated exposure may cause adverse reproductive effects. May cause fetal effects. Chronic exposure may cause liver damage. There is a danger of cumulative effects. Animal experiments show that small amounts of formamide, if repeatedly inhaled, ingested, or absorbed through the skin, can cause embryotoxi city. At levels sufficiently high to result in maternal illness, fetal malformations and fetal death have occurred. exposed (occlude d doses to intact skin) to dose level of 3000 mg/kg/day for 6 hrs/day, 5 days/week for 3 months had a decrease in the absolute weight of the testes and an increase in the number of rats with bilateral testicula r tubular atrophy.

Section 4 - First Aid Measures

Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool.
Extinguishing Media: Use dry chemical, carbon dioxide, or appropriate foam.
Flash Point: 154 deg C ( 309.20 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Provide ventilation.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Use only with adequate ventilation. Avoid breathing vapor or mist. Pregnant workers should keep exposure to a minimum.
Storage: Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Refrigeration has been recommended.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Formamide	10 ppm TWA; skin - potential for cutaneous absorption	10 ppm TWA; 15 mg/m3 TWA	none listed

OSHA Vacated PELs: Formamide: 20 ppm TWA; 30 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear, colorless
Odor: ammonia-like - weak odor
pH: 7.1 (0.5M aq soln)
Vapor Pressure: .06 mm Hg @ 25 deg C
Vapor Density: 1.6 (air=1)
Evaporation Rate:<1.0 (butyl acetate=1)
Viscosity: Not available.
Boiling Point: 210 deg C
Freezing/Melting Point:2-3 deg C
Decomposition Temperature:180 deg C
Solubility: Soluble.
Specific Gravity/Density:1.13 (water=1)
Molecular Formula:CH3NO
Molecular Weight:45.04

Section 10 - Stability and Reactivity

Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid: Light, moisture, temperatures >180°C as formamide will begin to partially decompose into carbon monoxide and ammonia.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, ammonia, isocyanates, phenols and cresols, iodine, sulfur trioxide, pyridine.
Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, ammonia.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

RTECS#:
CAS# 75-12-7: LQ0525000
LD50/LC50:
CAS# 75-12-7:
Draize test, rabbit, eye: 100 mg Severe;
Inhalation, rat: LC50 = >3900 ppm/6H;
Oral, mouse: LD50 = 3150 mg/kg;
Oral, rat: LD50 = 5577 mg/kg;
Skin, rabbit: LD50 = 17 gm/kg;
Carcinogenicity:
CAS# 75-12-7: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No information available.
Teratogenicity: Embryo or Fetus: Death, skin-rat TDLo=1200mg/kg; Stunted fetus, oral-rat TDLo=2g/kg. Specific Developmental Abnormalities: Craniofacial and Musculoskeletal, oral-rat TDLo=7980mg/kg.
Reproductive Effects: Fertility: Post-implantation mortality, oral-rat TDLo=2g/kg.
Neurotoxicity: No information available.
Mutagenicity: Please refer to RTECS LQ0525000 for mutation data.
Other Studies: See actual entry in RTECS for complete information.

Section 12 - Ecological Information

Ecotoxicity: No data available. Minnow LC50=>500mg/L/48H
Environmental: No information available.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	IATA	RID/ADR	IMO	Canada TDG
Shipping Name:	No information available.				No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL
TSCA
CAS# 75-12-7 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 75-12-7: Effective Date: 4/29/83; Sunset Date: 4/29/93
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 75-12-7: acute, chronic.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 75-12-7 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 61 May cause harm to the unborn child.
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 53 Avoid exposure - obtain special instructions
before use.
WGK (Water Danger/Protection)
CAS# 75-12-7: 1
Canada - DSL/NDSL
CAS# 75-12-7 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A.
Canadian Ingredient Disclosure List
CAS# 75-12-7 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 75-12-7: OEL-AUSTRALIA:TWA 10 ppm (15 mg/m3);Skin OEL-BELGIUM:
TWA 10 ppm (18 mg/m3);Skin OEL-DENMARK:TWA 20 ppm (30 mg/m3) OEL-FIN
LAND:TWA 20 ppm (37 mg/m3);STEL 30 ppm (55 mg/m3);Skin OEL-FRANCE:TWA
20 ppm (30 mg/m3) OEL-THE NETHERLANDS:TWA 20 ppm (30 mg/m3) OEL-RUS
SIA:STEL 3 mg/m3 OEL-SWITZERLAND:TWA 20 ppm (37 mg/m3) OEL-UNITED KI
NGDOM:TWA 20 ppm (30 mg/m3);STEL 30 ppm (45 mg/m3) OEL IN BULGARIA, C
OLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE,
VIETNAM check ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 12/12/1997
Revision #7 Date: 7/18/2002
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.